Biochemical study on the potential therapeutic use of novel curcumin copper oxide nanocomposite in diabetic complications in rats

Yakout A. Al-Senosy1 , Abd El-Bary M. Prince2 , Amira M. Abd El Zaher


The aim of this study was to investigate the hypoglycemic and antioxidant effect of Curcumin Copper Oxide nano-composite in STZ- induced diabetic rats. Sixty male rats were divided into four equal groups. Group 1 (control) comprised 15 rats received no drugs, Group 2 (Diabetic nontreated group) included 15 rats received no drugs, serve as STZ induced diabetic group. Group 3 (Diabetic nano-curcumin treated group) consists of 15 rats, received curcumin nanoparticle orally at a dose level of 2 mg/kg b.wt/day. Group 4 (Diabetic Curcumin Copper Oxide Nano-Composite treated group): included 15 rats, received curcumin Copper Oxide Nano-Composite at a dose level of 7 mg/kg b.wt/day orally. The obtained results revealed that, diabetic rats showed significant increase in serum glucose and Malondialehyde (MDA) concentrations. However, serum Superoxide dismutase (SOD) activity, Reduced Glutathione (GSH) and insulin concentration in pancreatic tissue were markedly decreased. Moreover, a significant down regulation in Insulin Receptor-A (IRA) and Insulin Receptors Substrate-2 (IRs-2) mRNA gene levels in hepatic tissue were observed in diabetic rats. Administration of Curcumin Copper Oxide Nano-Composite in diabetic rats caused significant improvement of all previous parameters. These results suggested that, Curcumin Copper Oxide Nano-Composite treatment may decrease the diabetic complications as hyperglycemia and oxidative stress in rats through free radical scavenging as well as regulation of endogenous antioxidant defense system mechanisms.

Key words

Diabetes mellitus, STZ- induced diabetes, Curcumin Copper Oxide Nano-Composite, oxidative stress

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