Biochemical Effect of Olive Leaves on Experimentally Induced Cardiac Stress in Rats

Abd El-Maksoud H.A., Raafat R. Mohammed and Nagih M. Hassan

Abstract

The present study was designed to evaluate the Protective effects of Olive laeves in Chronic myocardial necrosis induced experimentally in rats by subcutaneously injection with Isoproternol at adose of (5 mg/kg b.wt in 1 ml saline, s.c) weekly for 8 weeks . Blood samples were collected three times at the 3rd, 6th and one week after the 8th injection and 10 rats were sacrificed from each group at the time of blood samples. The present data showed that the experimental induction of cardiac necrosis accompanied by increases in the in mean values of serum Creatine kinase (CK)., Creatine kinase MB (CK-MB)., Lactate dehydrogenase (LDH)., Aspartate amino transferase (AST), glucose, erythrocytes Glucose 6 phosphate dehydrogenase. (G-6-PD), Potassium (K)., Phosphorus (P)., Total protein (T.P.), and albumin and cardiac muscles L- malondialdehyde (L-MDA).and significant decreases in heart tissues Superoxide Dismutase (SOD).and Catalase (CAT) and serum Calcium (Ca)., Sodium (Na).in the ISO group while the treatement with olive leaves retain these changes nearly to normal values

Key words

Creatine kinase, Catalase, Olive Leaves, Cardiac Stress