Preparation of rabies antiserum in tetanus immunized horses

Attyat, M. Kotb and Wafaa, R. Abdel Aziz

Abstract

The present work deals with the use of previously tetanus immunized horses for preparation of rabies antiserum in addition to investigate the effect of simultaneous immunization of horses against rabies and tetanus in order to prepare a bivalent anti-rabies and tetanus serum. The obtained results of applied serological tests revealed that the presence of tetanus antibodies in previously immunized horses did not affect the levels of induced rabies antibodies while simultaneous immunization resulted in high titers of rabies antibodies (256 IU/ml) as compared to such titers resulted in horses immunized with rabies vaccine alone (128 IU/ml). These findings suggest an enhancing action of tetanus antigen on antibody response against rabies and the prepared anti-serum can be used in emergency bite injuries in animals protecting them against both of rabies and tetanus infections as noticed in experimentally rabies infected mice.

Key words

Rabies, Tetanus, Antiserum, Anti- rabies, Horses