Abstract of research

Biochemical changes in carbohydrates metabolism in experimentally induced rheumatoid arthritis in rats.

1Omnia M. Abd Elhamid, 2Khaled Mohamed Fararh, 3 Mona Nawar Abdel Ghany

Abstract

In the present study, the effect of Complete Freund`s adjuvant - induced rheumatoid arthritis on serum Glucose, Nitric Oxide, Cortisol, Lactic acid, Pyruvic acid, Pantothenic acid, Pentosidine, Na/K ATPase, Interleukin 8 and Sialic acid in rats have been evaluated. Forty female albino rats were divided into two equal groups (20 each). Group Ι (Control group): received no drugs. Group II: (Rheumatoid Arthritis group) injected subcutaneously with Complete Freund`s adjuvant at a dose of (0.1 mg /kg body weight dissolved in 1 ml saline) for rheumatoid arthritis induction. Blood samples were collected from all groups after 2 and 4 weeks from injection. The obtained results showed that there is the experimental arthritis accompanied with significant increases in serum Glucose, Nitric oxide, Cortisol, Lactic acid, Pentosidine, Interleukin 8 and Sialic acid levels. On the other hands, pyruvic acid level, Na/k ATPase activity and pantothenic acid levels were significantly decreased.