Abstract of research

BIOCHEMICAL EFFECT OF CURCUMIN, GARLIC EXTRACT AND OLIVE OIL ON HYPERLIPIDEMIA INDUCED IN RATS

Omayma, A. Ragab*; Afaf, D. Abdel-Majeed*; Kamel, M. Hassanin** and Mostafa, M. Abdelghaffar*.

Abstract

This study was performed to investigate the effect of oral supplementation of curcumin, garlic extract and olive oil on lipid profile, nitric oxide, adiponectin, endothelin-1, blood glucose and some inflammatory markers in normal, diabetic and hyperlipidemic rats supplementing high fat and cholesterol-enriched diet. Eighty female adult albino rats were divided into eight equal groups of 10 rats each. Group (1): negative control received normal diet only, group (2): rats fed on normal diet and received curcumin orally, group (3): rats fed on normal diet and receive garlic extract (1 ml/100g b.w.) orally, group (4): rats fed on normal diet and receive olive oil (0.5 ml/100g b.w.) orally, group (5): positive control received hyperlipidemic diet, group (6): rats fed on hyperlipidemic diet and received curcumin (350 mg/ 1 kg b.w.) orally, group (7): rats fed on hyperlipidemic diet and received garlic extract orally, group (8): rats fed on hyperlipidemic diet and received olive oil orally. The obtained results revealed that, curcumin, garlic extract and olive oil supplementations to hyperlipidemic rats showed a significant increase in serum HDL-cholesterol, nitric oxide, adiponectin and Endothelin-1 concentrations and significantly decrease in serum total cholesterol, triacylglycerols, LDL-cholesterol, Fasting blood glucose, Glycated Hemoglobin (HbA1C), high sensitive C-reactive protein and Interleukin-6 levels. These results suggest that, curcumin, garlic extract and olive oil supplementations may have some benefits in patients suffering from dyslipidemia and diabetes.