TOXICOLOGICAL EFFECT OF COPPER SULPHATE AND COBALT CHLORIDE AS FEED ADDITIVES ON FERTILITY IN MALE ALBINO RATS.

Saida A. Mohammed; Bakery H. H.; Abuo Salem M. E.; Nabila, A. M. and Elham,A. E.

Abstract

This study is designed to investigate the effect of copper sulphate and cobalt chloride, which are used as additives in feed on fertility of male white albino rats. One hundred rats classified to five groups. First group used as control; second and third group were given 1/10 and 1/5 LD50 of CuSo4 respectively, fourth and fifth groups were given 1/10 and 1/5 LD50 of CoCl2 respectively (orally via stomach tube). Testis and epididymis were dissected and used for detection of sperm motility and counts. Histopathological examination was performed on testis. Results showed significant decrease in testis and epididymis weight and significant increase on sperm abnormalities while sperm numbers were significantly decreased. It can be concluded that ingestion of copper sulphate and cobalt chloride in high doses decrease fertility in male albino rats.

Key words

cobalt toxicity- copper toxicity – spermatogenesis- heavy metals.