Comparative Study between the Use of Bulk and Nanoparticles of Zinc Oxide in Amelioration the Toxic Effects of Aflatoxins in rats

Salwa Reyad Abd El-Fatah1, Hatem Hussien Bakry2, Mohamed Elsayd Sobhy Abo Salem2 and Atef Abd-Elaziz Hassan3


The ability of zinc oxide nanoparticles (ZnO-NPs) to ameliorate the toxic effect of aflatoxin B1 (AFB1) in rats in comparison with traditional bulk zinc oxide was evaluated in this study. Two doses of bulk zinc oxide and ZnO-Nps (25 and 50 μg/kg body weight rat of each) were given orally to rats experimentally treated with 50μg/kg b.wt rat AFB1 produced by aflatoxigenic Aspergillus flavus strains. The experimental study extended for further 30 days. The obtainedresults revealed that the low doses of zinc oxide nanoparticles were more effective than low or high doses of bulk ZnO in amelioration the toxic effects of aflatoxicosis which reflected as enhancement in antioxidant activity and histopathological picture of aflatoxicated rats.

Key words

ZnO-NPs- Aspergillus flavus- aflatoxin B1- aflatoxicosis -amelioration.

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