Protective Effect of Curcumin Against Adverse Effects of Meloxicam in Rats

El-Sayed, M.G.A.1; El-Komy, A.A.A.1 and Amany, Abd Al-Wahed2

Abstract


The aim of the present study was to determine the adverse effects of meloxicam on lipid profile, glucose profile and hematology as well as the protective effect of curcumin in rats. Thirty-six male Wister albino rats were randomly divided into main four groups; Group (1): control (administered saline only 0.5 ml); Group (2): meloxicam was administered intraperitoneally at level of 5.8 mg/kg body weight for 15 days; Group (3): curcumin extract was administered orally at level of 200 mg/kg body weight for 15 days; Group (4): were administered meloxicam intraperitoneally with oral administration of curcumin extract for 15 days. The findings revealed that there were significant increase in serum cholesterol level and serum triglycerides level of rat given meloxicam. There were significant decrease in serum cholesterol level and serum triglycerides of rats administered meloxicam with curcumin group. There was a significant increase in serum glucose level of rat given meloxicam. There was significant decrease in serum glucose level of meloxicam with curcumin group compared to meloxicam group. There was alteration in hematological parameters of rat given meloxicam. On the contrary, there was an improvement in hematological tests of meloxicam with curcumin group and improvement of histopathological study compared to meloxicam. On conclusion, administration of meloxicam intraperitoneally 5.8 mg/kg body weight resulted in impairment in lipid profile, glucose profile and hematological parameters and these impairments could be improved by curcumin administration.

Key words


Meloxicam; curcumin; lipid profile; glucose profile; blood pictures.

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