Biochemical studies on the effect of curcumin in experimentally induced osteoarthritis in rats

Yakuot A. El-senosi1, Ashraf A. El komy2 and MoKhtar, A1.

Abstract


Osteoarthritis (OA) is the most common disease of joints in adults around the world. Osteoarthritis was induced in rats by intra-articular injection of 2 mg/kg b.wt of monosodium-iodoacetate (MIA). Thirty six male, albino rats were divided into four equal groups. 1st group was not subjected to any intervention and was used as normal control. 2nd group (OA - induced group) received injection of MIA intra-articular. 3rd group ( OA+ curcumin treated group) injected MIA and treated with 200 mg/kg b.wt of curcumin orally and daily / 28 day. 4th group ( curcumin normal group) received 200 mg/kg b.wt of curcumin orally and daily / 28 day. Blood samples were collected at 28th day. The obtained results showed a significant increase in MDA level and SOD activity in MIA induced OA. On the other hand, a significant decrease in GSH, GPx, CAT and GAG were observed in OA induced rats. Curcumin treatment in OA induced rats significantly increased GSH concentration , GPx, CAT and GAG activities with marked decrease in MDA concentration. In conclusion, the present study demonstrated that curcumin administration provided an effective protection and treatment against OA and oxidative damage in MIA injected rats.

Key words


OA, curcumin, inflammatory mediators, oxidative damage.

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