Effect of gentamicin and thioacetamide toxicity on serum proteins

Abd-Elrahman N.M., Farid, A. S. and Fararh, K.M.

Abstract

Forty-four male Wister rats were divided into four groups. group one (CN) (control group for gentamicin) was used as control(n=9). group two (Neph) (treated group for gentamicin) was injected subcutaneously with 100 mg/kg body weight /day/3 days(n=15). group three(CC) (control group for thioacetamide)was used as control (n=10).group four (cirrhosis)(treated group for thioacetamide)was injected 200mg/5ml saline /kg body weight of thioacetamide I/P for three times per week for 7 weeks(n=10).Results showed that there was significant decrease in total protein, albumin and A/G ratio in(Neph) (treated group for gentamicin) when compared to its control group (CN), furthermore there was significant decrease in concentration of total proteins, albumin, α1gloublin, α2 globulin and β globulin in treated group for thioacetamide. these results showed that different changes of serum protein in rats

Key words

Serum protein, gentamicin, thioacetamide, rat.