Biochemical effect of cranberry extract on experimentally induced myocardial infarction

Hussien A. Ali, Omnia A mahmoud, Mohammed A. Hussein, Mariam S. Mohammed

Abstract

Myocardial infarction (MI) is characterized by an inequity of coronary blood supply and demand, which results in myocardial ischemic injury and damages the cardiomyocytes. Isoproterenol (ISO) is a synthetic catecholamine cause toxicity leading to severe stress in the myocardium of experimental animals. The aim of the present article is to investigate cardioprotective activity of cranberry extract against ISO-induced cardiotoxicity in adult rats. Oral administration of cranberry extract at a concentration of 75 and 150 mg/kg b.wt. daily for 28 days showed a significant protection against-induced alteration in plasma total cholesterol (TC), triacyclglycerols (TG), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C), tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO) as well as cardiac superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced glutathione (GSH), catalase (CAT) levels. In addition, cranberry extract reduced plasma Creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) as well as cardiac thiobarbituric acid reactive substances (TBARS) levels (MDA) as compared to control group. In conclusion, cranberry extract renders resiliency against isoproterenol cardiotoxicity due to its antioxidant and free radical scavenging activity.

Key words

Cranberry extract, isoproterenol, myocardial infarction, antioxidant