Abstract of research

TOXICITY OF LAMBDA CYHALOTHRINE ON ERYTHROGRAM, LIVER AND KIDNEY WITH MOLORATED BY VITAMINE C.

Rania M. Waheed, Bakery, H.H., El-Shawarby, R.M. and Abou Salem, M.E.

Abstract

Lambda cyhalothrin is a new pyrethroid insecticide used all over the world to control the insect on wide rang in a variety of crops, and used as vector control (mosquito). The present study was designed to investigate the protective effect of vitamin C on the toxicological effects of lambda cyhalothrin-on erythrogram, liver and kidney enzyme activities and histopathological changes. In this study 80 male albino rats (western strain) were dividied in to 4 groups each group contain 20 rats. First group kept as control, second group was given vitamin C at dose 200ppm in drinking water daily for 2 month, third group was given 100 mg/kg/B.w lambada cyhalothrine 3 day per week for 2 month orally by using stomach tube while fourth group was given lambada cyhalothrine at dose l00mg/kg/Bw three time/week orally by stomach tube plus vitamin C 200ppm in distal ill water daily continuously for 2 month. The obtained results were significant decrease on erythrocyte, hemoglobin and pcv% in group of rats received lambada cyalothrine. While ALT, AST, AP, creatinine, urea and uric acid were significantly increased but the total protein, albumin and globuline were significantly decreased in rats received-lambada cyhalothrine in compared with other groups. This parameters were non-significant difference in control group and group received vitamin C but improved in the group rats received lambada cyhalothrine plus vitamin C.