Abstract of research

The biochemical effect of curcumin and chromium administration on adiponectin secretion and metabolism in experimentally diabetic rats by streptozotocin.

Omayma A.R. AbouZaid 1; Sawsan.M.El-sonbaty 2 and Mohsen.W.F.Afifi 1

Abstract

In the present study, the potential therapeutic effect of Curcumin combined with Chromium administration on adiponectin secretion and its biochemical effects on serum glucose, total cholesterol, triglycerides, LMalondialdehyde (MDA), reduced glutathione (GSH), Interleukin 6 (IL-6) and Peroxisome proliferatoractivated receptor gamma (PPAR-) of adipose tissue in experimentally diabetic rats by streptozotocin (STZ) have been evaluated. Fourty male Albino rats were divided into four equal groups of 10 rats each. Group Ι (Control group): received no drugs. Group Π :( normal rats treated with curcumin and chromium): Group III : (Diabetic rats group): received a single dose of Streptozotocin (STZ) (50-mg/kg i.p) and was used for diabetes mellitus induction. Group IV:(Diabetic rats + Curcumin + Chromium treated group): treated with curcumin combined with chromium for 21 days after diabetes induction. Blood samples and adipose tissue were collected at the 22th day from the onset of curcumin and chromium administration. The obtained results showed that, STZ-induced diabetes causing a significant increase in serum glucose, total cholesterol, triglyceride, L-MDA, and IL-6 and a significant decrease in adiponectin secretion, GSH level and PPAR-γ expression. Curcumin combined with chromium was able to mitigate diabetes induced by STZ through decreasing serum glucose, total cholesterol, triglyceride, L-MDA, and IL-6 and increasing adiponectin secretion, GSH level and PPAR-γ expression. These results suggest that, curcumin and chromium combination may be effective in increasing insulin sensitivity in diabetic rats by increasing adiponectin secretion and exhibiting anti-inflammatory, antioxidant effects.