ADIPONECTIN AND MYELOPEROXYDASE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Hussein Abd El Maksoud a,*, Yaser M. Abdel-Nabi a and Raafat R. Gindi b

Abstract

To evaluate the relationship between plasma adiponectin levels, myeloperoxidase (MPO), lipid profile and serum nitrite/nitrate in patients with acute myocardial infarction (AMI), thirty AMI patients and 10 clinically healthy subjects (control), aged 35 - >70 years, were used. The results of the present study showed the association between Adiponectin and MPO concentration, Nitrite and Nitrate levels, in addition to serum lipid profile including (total cholesterol, Triacylglycerol (TG), Low density lipoprotein – cholesterol (LDL-ch) and High density lipoprotein-cholesterol (HDL-ch) and acute phase of myocardial infarction in patients. These parameters may be regarded as predictors or risk factors for AMI and suggesting that, hyperlipidemia and vascular inflammation, and oxidative stress are primary interacting mediators in the pathogenesis of AMI.

Key words

Acute myocardial infarction, Adiponectin, Hyperlipidemia, Myeloperoxidase, Vascular inflammation