Abstract of research

ASSOCIATION OF INFLAMMATORY, ENDOTHELIAL DYSFUNCTION MARKERS AND CARDIOVASCULAR RISK FACTORS IN OVARIECTOMIZED STZ-DIABETIC RATS

Omayma, A.R. Abo-zaid, Goda, A. and Sahar E. Ahmed.

Abstract

The present study was carried out on eighty female albino rats. They were randomly divided into fourth groups ;the first group involved twenty rats was sham operated control group, the second group was subjected to induction of diabetes type 2 rats were injected with (125 ml/kg nicotinamide) ¼ hour before injection with streptozotocin 60 ml/kg, the third group consist of 20 rats was rendered to bilateral ovariectomy .the fourth group Consists of 20 rats was subject to bilateral ovariectomy and induction of type 2 diabetes. Biochemical investigation involved the measurement of total cholesterol , triacylglycerol , high density lipoprotein (HDL) , low density lipoprotein (LDL) , nitric oxide (NO) , hs-CRP, and TNF-α. The results of the present study indicate that inflammation, unfavorable lipid profile in form of significant increase of total cholesterol, triacylglycerol, and low density lipoprotein (LDL). Meanwhile, the serum nitric oxide in diabetic rats as well as those of ovarictomy were significantly different from those of control. However, serum nitric oxide and, high-density lipoprotein (HDL) concentration in the ovarictomy STZDiabetic rats was highly significant decrease compared to those of sham-operated group.