Marwa A. Elsenhwy1, Bakry. H.H. 2, El- Ahawarby. R.M. 2, Abou Salem, M. E. 2 and Elham A. El-shewy 2


Florfenicol, (structural analogue of thiamphenicol) is of great value in veterinary treatment of infectious diseases. The present study was designed to investigate the immune-suppressive action of Florfenicol either on humeral or cellular immunity. In this study 160 one day old COBB broiler chicks divided into 4 groups each group contain 40 birds, First group (G1) received 120 mg/kg b.wt, second group (G2) received 60 mg/kg b.wt, while third group (G3) received 30 mg/kg b.wt, Florfenicol which given orally in drinking water once/a day 4 times /week for 6 weeks while forth group (G4) kept as control. The obtained results were decrease of body weight, decreased no of RBCs and WBCs counts, Hb and PCV, decrease of phagocytic activity, decreased (DLC) (Lymphocytes, Basophil, Oesinophils, heterophil and monocytes and about humeral immunity investigated that Florfenicol administration decreased serum albumin and α, β and γ globulins, also decreased ND antibody titers the decrease in these parameters is highly significant in G1 and significant in G2 and non significant in G3 compared to the control, from our results we concluded that Florfenicol is an immune-suppressive drug in dose dependent manner.

Key words

florfenicol, Immunotoxicity, broiler chicken.

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