RESIDUAL STUDIES OF FLORFENICOL IN BROILER CHICKEN

Marwa A. Elsenhwy1, Bakry. H.H. 2, El- Ahawarby. R.M. 2, Abou Salem, M. E. 2 and Elham A. El-shewy 2

Abstract


Florfenicol, (a structural analogue of thiamphenicol) is of great value in veterinary treatment of infectious diseases. This study was designed to investigate the toxicological effects of florfenicol on different organs, liver and kidney activities, histopathological changes with regard to the residues of Florfenicol in organs and tissue. In this study 160 one day old COBB broiler chicks divided into 4 groups each group contain 40 birds. First group (G1) received 120 mg/kg b.wt, second group (G2) received 60 mg/kg b.wt, while third group (G3) received 30 mg/kg b.wt, Florfenicol which given orally in drinking water once/a day 4 times /week for 6 weeks while forth group (G4) kept as control. The obtained results were reduction in weights of liver, heart, lung, brain and proventriculus, with significant increase in weights of kidney and gizzard in G1 and G2 respectively. Increase of Creatinine, AST and ALT in broiler chicken of G1and G2 with nonsignificant effect on G3 comparable to G4 (control) were recorded. High concentration of florfenicol in kidney, liver, spleen, lung, heart, thigh and breast muscle 2 days and 4 days after last dose were measured while moderate concentration of florfenicol after 6-dayes were detected. Low concentration of Florfenicol in kidney and liver only detectable at 8-dayes after last dose.

Key words


florfenicol, residues, broiler chicken.

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