EFFECT OF TILMICOSIN ON ISOLATED SMOOTH AND CARDIAC MUSCLES AND NEUROMUSCULAR JUNCTIONS

Elsayed M. G.a, Elkomy A. A.a, Mona. A. Elkholyb,*

Abstract


The pharmacodynamic effects of tilmicosin on smooth muscles were investigated in isolated organs. As the effect of graded increased concentrations of tilmicosin on isolated rat’s uterine muscles was examined during various stages of sex cycles. Tilmicosin in the tested concentrations produced a dose-dependent negative inotropic effect on isolated rabbit’s heart and guinea pig’s auricles. Tilmicosin in all tested concentrations did not induce any effects on the isolated guinea pig’s tracheal chain and rabbit’s aortic strips. Neuromuscular blockade effect was investigated on isolated frog’s gastocnemius muscles and rectus abdominis muscle preparations. It was concluded that, tilmicosin directly stimulate smooth muscles of gastrointestinal tract and depresses those of uterus in various stages of sex cycle as well as cardiac muscles. Tilmicosin might act directly to induce neuromuscular blockade. It was concluded that tilmicosin scarcely any pharmacological properties which might be leading to severe adverse reaction in clinical use.

Key words


Cardiac muscles, neuromuscular junctions, smooth muscles, tilmicosin.

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